The Oxford Musculoskeletal BioBank is a resource aimed at research groups that are studying neoplastic and non-neoplastic disorders of bone joint and soft tissue. Primarily, this resource is aimed at research groups working within the Botnar Research Centre and the Nuffield Orthopaedic Centre. In addition, we would like to promote this resource nationally to external collaborators and research groups from external institutions.
In order to study these disease processes, human tissue is required, and through close collaboration with the Nuffield Orthopaedic Centre, we propose to collect samples from operations performed there. Most orthopaedic research units share a similar symbiotic relationship with their local hospital.
All samples obtained are tissues that are either normally disposed of at the time of surgery: cartilage, bone, synovium, synovial fluid, bone marrow, and tendon; or are surplus to diagnostic requirements: tumour samples, normal tissue samples. In both cases the patients care remains the same and their diagnosis is in no way compromised.
In addition to samples obtained during a surgical procedures we would also like to routinely collect samples of blood and urine which will enable the BioBank to supplement the data held for each donor.
In summary, the OMB is an NRES approved research tissue bank which holds its own HTA licence for the storage of human tissue for the purpose research. We were inspected in September 2010 and received very positive and encouraging feedback. We have facilities to collect, process and store human blood, urine and intra operative or diagnostic "waste" tissue, i.e. tissue that would ordinarily be disposed of. In addition, we collect an outstanding amount of phenotypic data. Our goal is to recruit all patients that attend the NOC for medical and surgical care.
Only appropriately consented patients will be entered into the BioBank.
We operate a controlled access policy and any applications for access to material are scrutinised and reviewed by the OMB access committee to ensure end use falls within the scope of our own ethical boundaries.
All research groups that wish to use the BioBank must apply through the OMB Access Committee. Only projects that are covered by the scope of this application will be authorised. In addition to obtaining approval from the Access Committee, if a research group wishes to start their own sub-collection or enter an existing collection under the cover of the Oxford Musculoskeletal BioBank, the researcher must provide evidence that they comply to the BioBank's policies on storage, health & safety, disposal, security, quality management, access, training and consent. Evidence can be in the form of Standard Operating Procedures. These policies have been put in place to ensure HTA compliance.
Tissue and data will only be released to external research groups if they hold appropriate ethics committee approval and all transfers will be made with a Material Transfer Agreement in place.